Engineering strategies to mimic the glioblastoma microenvironment
نویسندگان
چکیده
منابع مشابه
Engineering strategies to mimic the glioblastoma microenvironment.
Glioblastoma multiforme (GBM) is the most common and deadly brain tumor, with a mean survival time of only 21months. Despite the dramatic improvements in our understanding of GBM fueled by recent revolutions in molecular and systems biology, treatment advances for GBM have progressed inadequately slowly, which is due in part to the wide cellular and molecular heterogeneity both across tumors an...
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Glioblastoma multiforme (GBM) is a devastating type of tumor with high mortality, caused by extensive infiltration into adjacent tissue and rapid recurrence. Most therapies for GBM have focused on the cytotoxicity and have not targeted GBM spread. However, there have been numerous attempts to improve therapy by addressing GBM invasion, through understanding and mimicking its behavior using thre...
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ژورنال
عنوان ژورنال: Advanced Drug Delivery Reviews
سال: 2014
ISSN: 0169-409X
DOI: 10.1016/j.addr.2014.08.012